one-way anova with dunnett’s multiple comparisons test or tukey’s multiple comparisons test in graphpad prism 7.0  (GraphPad Software Inc)

Journal: Pharmacological Reports

Article Title: Levomepromazine and clozapine induce the main human cytochrome P450 drug metabolizing enzyme CYP3A4

doi: 10.1007/s43440-020-00157-4

Figure Lengend Snippet: Viability of cryopreserved human hepatocyte after treatment with a series of concentrations (0.01–200 µM) of levomepromazine a or of clozapine b . The results are shown as the percent of control (mean ± SEM, n = 3). One-way ANOVA, Dunnett’s test: ** p < 0.01 and **** p < 0.0001 versus respective control

Article Snippet: Statistical analysis of activity, LDH and mRNA levels was performed using one-way analysis of variance (ANOVA) followed by Dunnett’s post hoc test (GraphPad Prism 7.0).

Techniques: Control

Journal: Pharmacological Reports

Article Title: Levomepromazine and clozapine induce the main human cytochrome P450 drug metabolizing enzyme CYP3A4

doi: 10.1007/s43440-020-00157-4

Figure Lengend Snippet: The effect of rifampicine, levomepromazine and clozapine on the CYP3A4 activity and mRNA level in cryopreserved human hepatocytes from three different lots. a CYP3A4 activity level was measured as the rate of testosterone 6β-hydroxylation and presented as the percent of control. The control values for CYP3A4 activity (pmol/mg protein/min) were: 0.13 ± 0.01 for HU1832, 0.04 ± 0.004 for HU1663 and 0.07 ± 0.001 for HU1836. b The CYP3A4 mRNA level was presented as fold change upon drug treatment (mean ± SEM, n = 5). One-way ANOVA (see Table ), Dunnett’s test: * p < 0.5; ** p < 0.01; *** p < 0.001; ****p < 0.0001 versus respective control

Article Snippet: Statistical analysis of activity, LDH and mRNA levels was performed using one-way analysis of variance (ANOVA) followed by Dunnett’s post hoc test (GraphPad Prism 7.0).

Techniques: Activity Assay, Control